کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9037584 | 1133445 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytokine transcript profiling in CD34+-progenitor derived dendritic cells exposed to contact allergens and irritants
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
We observed a large inter-individual variation in mRNA expression in CD34-DC exposed to the chemicals. No or limited effects on expression were observed for the irritant BC and the weak sensitizer eugenol. All other chemicals modulated the transcript levels of most cytokines that were investigated. Most of the time, no clear-cut distinctions could be made between the sensitizers and SDS. After 24Â h, consistent upregulatory effects of all sensitizing compounds on transcript expression of CCL2, CCL3 and CCL4 were observed, whereas SDS (and BC) had no effect. Our findings suggest that the CCL2, CCL3 and CCL4 genes may be selective end-point markers in the CD34-DC model to discern chemical sensitizers from irritants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 155, Issue 1, 15 January 2005, Pages 187-194
Journal: Toxicology Letters - Volume 155, Issue 1, 15 January 2005, Pages 187-194
نویسندگان
Geert R. Verheyen, Elke Schoeters, Jean-Marie Nuijten, Rosette L. Van Den Heuvel, Inge Nelissen, Hilda Witters, Vigor F.I. Van Tendeloo, Zwi N. Berneman, Greet E.R. Schoeters,