The Combination of Fludarabine, Cyclophosphamide, and Granulocyte-Macrophage Colony-Stimulating Factor in the Treatment of Patients with Relapsed Chronic Lymphocytic Leukemia and Low-Grade Non-Hodgkin's Lymphoma

The combination of fludarabine and cyclophosphamide is a well-tolerated and effective treatment regimen for patients with relapsed CLL and low-grade NHL. A higher percentage of complete responses were noted in patients with low-grade NHL compared with patients with CLL. Granulocyte-macrophage colonystimulating factor did not seem to decrease the incidence of febrile neutropenia. However, the higher number of complete and partial responses noted on the GM-CSF arm is intriguing and warrants further investigation.