Absence of Lower Urinary Tract Symptoms Is an Independent Predictor for Cancer at Prostate Biopsy, but Prostate-Specific Antigen Is Not: Results from a Prospective Series of 569 Patients

This prospective analysis of 569 men demonstrates that traditional indicators for PNB (abnormal DRE findings and PSA levels) are not significant predictors of prostate cancer. Independent predictors for prostate included age, low AUASS, low PV, and abnormal TRUS findings. A low AUASS (indicative of the absence of benign disease) is an important predictor of prostate cancer.