کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9110332 | 1155014 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The metabolic consequences of childhood obesity
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کلمات کلیدی
Type 2 diabetes (T2DM)adiponectin - آدیپونکتینImpaired glucose tolerance (IGT) - اختلال تحمل گلوکز (IGT)Non-alcoholic fatty liver disease (NAFLD) - بیماری کبدی چرب غیر الکلی (NAFLD)Metabolic syndrome - سندرم متابولیکInsulin resistance - مقاومت به انسولینC-reactive protein (CRP) - پروتئین واکنش C (CRP)Visceral fat - چربی احشایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The prevalence of childhood obesity is increasing worldwide, as is the prevalence of obesity-related co-morbidity. Altered glucose metabolism, manifested as impaired glucose tolerance (IGT), appears early in obese children and adolescents. Obese young people with IGT are characterized by marked peripheral insulin resistance and a relative β-cell failure. Lipid deposition in muscle and the visceral compartment, and not only adiposity per se, is related to increased peripheral insulin resistance, the 'driving force' of the metabolic syndrome. Other elements of the metabolic syndrome, such as dyslipidemia and hypertension, are already present in obese youngsters and worsen with the degree of obesity. Similarly, markers of systemic 'low-grade inflammation' worsen with increasing adiposity. The long-term impact on cardiovascular and liver morbidity of obesity-related insulin resistance in young people is expected to emerge as these youngsters become young adults.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Endocrinology & Metabolism - Volume 19, Issue 3, September 2005, Pages 405-419
Journal: Best Practice & Research Clinical Endocrinology & Metabolism - Volume 19, Issue 3, September 2005, Pages 405-419
نویسندگان
Ram Weiss, Sonia (Professor of Pediatrics),