کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9118991 | 1158070 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of dietary ratios of fatty acids on cholesterol metabolism in rats and on low-density lipoprotein uptake in hepatocytes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The effects of different dietary ratios of polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) to saturated fatty acids (SFAs) [(PUFA+MUFA)/SFA] on plasma and hepatic lipids, the activities of hepatic regulatory enzymes of cholesterol metabolism, and low-density lipoprotein (LDL) uptake of hepatocytes and Kupffer cells were examined. In this study, 2 different types of diets that had the same PUFA/SFA ratio of 1.0 but each with different (PUFA+MUFA)/SFA ratios of 1.4 (diet 1, control) and 5.7 (diet 2), respectively, were fed to rats. Rats fed with diet 2 showed significantly increased plasma total triacylglycerol (TAG; 21%), very low density lipoprotein (VLDL) TAG (28%), and VLDL cholesterol (113%) levels compared with those fed with diet 1. Plasma LDL cholesterol concentration was not different between the 2 dietary groups of rats. Rats fed with diet 2 also had significantly increased hepatic cholesteryl ester concentrations (155%) and excreted less neutral sterol (35%) compared with rats in the diet 1 group. The activities of hepatic acyl coenzyme A (CoA):cholesterol acyltransferase and cholesterol 7α-hydroxylase for rats in diet group 2 were significantly increased (38% and 39%, respectively), and hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity decreased (21%) compared with the values in diet group 1. Uptake of LDL by hepatocytes (106%) and Kupffer cells (140%) was higher in rats fed with diet 2 compared with rats fed with diet 1. In summary, the diet with a high ratio (PUFA+MUFA)/SFA increased plasma total TAG, VLDL TAG, and VLDL cholesterol concentrations and liver cholesteryl ester by elevating hepatic acyl CoA:cholesterol acyltransferase and 7α-hydroxylase activities, lowering hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity, and increasing LDL uptake by hepatocytes and Kupffer cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 25, Issue 8, August 2005, Pages 781-790
Journal: Nutrition Research - Volume 25, Issue 8, August 2005, Pages 781-790
نویسندگان
Nai-Wen Chang, Chen-Ten Wu, Fei-Na Chen, Po-Chao Huang,