کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9148763 1166104 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Down-regulated reactive oxygen species by HSP90 in 3HK-induced SKN-SH cell death
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Down-regulated reactive oxygen species by HSP90 in 3HK-induced SKN-SH cell death
چکیده انگلیسی
In this present study, we show that 3HK induced reactive oxygen species (ROS) accumulation and after caspase activation lead to apoptotic cell death. Pretreatment with N-acetylcysteine (NAC), an effective antioxidant, significantly attenuated 3HK-induced apoptosis by way of a reduction of ROS accumulation and caspase activity. SKN-SN cells were protected from 3HK-induced cytotoxicity by heat shock protein (HSP). HSP effectively attenuated 3HK-mediated ROS accumulation and apoptosis. In addition, the protective effect of HSP90 was abolished by pretreatment with HSP90 anti-sense oligonucleotides, but not when pretreated with anti-senses for other HSPs. These results suggest that HSP90 protects SKN-SH cells from 3HK-induced cytotoxicity by reducing ROS levels and caspase activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Thermal Biology - Volume 30, Issue 1, January 2005, Pages 43-49
نویسندگان
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