Immunizable diseases and Down syndrome

People with Down syndrome (DS) are especially infection-prone, particularly during childhood. The main reason is an association of DS with multifactorial primary immune deficiency. Many of these conditions are immunizable, but studies of vaccination and DS are few and do not include recent formulations. While awaiting remediation of this gap, the present state of knowledge is that available vaccines are safe and effective for people with DS, though the possibility that response may be lower than average means that strict compliance with immunization schedules is required to ensure effectiveness.