Hyperthermie maligne

Autosomal dominant malignant hyperthermia is revealed by anaesthetic agents (halothane, succinylcholine). The disease is due to a calcium leak through sarcoplasmic reticulum. Contracture tests are to be performed for the diagnosis. A ryanodine receptor gene mutation is observed in 40% of families. Heterogeneity characterizes other cases. Central core disease is a frequently associated disease that must be sought. Cases of exercise malignant hyperthermia have been identified.