کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9190355 | 1186000 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Motor performance and behavior of immature rats are not compromised by a high dose of topiramate
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
The first step in a study of possible cognitive side effects of topiramate in immature rats is to determine if and how topiramate (TPM) influences motor ability and spontaneous behavior. We therefore studied the effects of TPM on motor performance of 12- and 25-day-old rats using age-appropriate tests. Spontaneous behavior in the open field was studied in 25-day-old animals only. TPM was administered intraperitoneally at 80 and/or 160Â mg/kg; control rats were injected with solvent (dimethylsulfoxide). A battery of motor tests was conducted before and 1, 3, and 24Â hours after administration; behavior in the open field was recorded 2 and 24Â hours after TPM administration. The effects of TPM on motor performance were similar to those of solvent. A few differences were found only at the 3-hour interval in 12-day-old rats. Behavior in the open field was not impaired by TPM; on the contrary, an apparent anxiolytic effect was observed. Habituation (a decrease in locomotor activity during the 5-minute observation period), a form of simple nonassociative learning, was also not compromised by TPM. A single high dose of TPM resulted only in transient changes in motor performance. A possible anxiolytic effect observed in 25-day-old rats should be studied.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 7, Issue 2, September 2005, Pages 222-230
Journal: Epilepsy & Behavior - Volume 7, Issue 2, September 2005, Pages 222-230
نویسندگان
Mariam Alaverdashvili, Hana Kubová, Pavel MareÅ¡,