کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9190451 | 1186003 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Correlation between shaking behaviors and seizure severity in five animal models of convulsive seizures
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Correlation between shaking behaviors and seizure severity in five animal models of convulsive seizures Correlation between shaking behaviors and seizure severity in five animal models of convulsive seizures](/preview/png/9190451.png)
چکیده انگلیسی
Wet dog shakes (WDS) and head shakes (HS) are associated with experimentally induced convulsive seizures. We sought to determine whether these behaviors are correlated or not with major (status epilepticus (SE) or fully kindled animals) or minor (non-SE or partially kindled animals) seizure severity. WDS are directly correlated with SE induced by intracerebral star fruit extract (Averrhoa carambola) injection and with kindled animals in the amygdala fast kindling model. On the other hand, WDS are inversely correlated with SE induced by intracerebral bicuculline and pilocarpine injections. Systemic pilocarpine in animals pretreated with methyl-scopolamine barely induced WDS or HS. The role of shaking behaviors may vary from ictal to anticonvulsant depending on the experimental seizure model, circuitries involved, and stimulus intensity. The physical presence of acrylic helmets may per se inhibit the HS response. Also, methyl-scopolamine, a drug incapable of crossing the blood-brain barrier, can induce HS in animals without acrylic helmets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 6, Issue 3, May 2005, Pages 328-336
Journal: Epilepsy & Behavior - Volume 6, Issue 3, May 2005, Pages 328-336
نویسندگان
Marcelo Cairrão Araújo Rodrigues, Franco Rossetti, Maira Licia Foresti, Gabriel Maisonnave Arisi, Márcio Araújo Furtado, Maria Luiza Cleto Dal-Cól, Poliana Bertti, Artur Fernandes, Francisco Leite Santos, Flávio Del Vecchio,