کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194646 | 1580508 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of light chain immunoglobulin in urine from animals and humans infected with prion diseases
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Characterization of light chain immunoglobulin in urine from animals and humans infected with prion diseases Characterization of light chain immunoglobulin in urine from animals and humans infected with prion diseases](/preview/png/9194646.png)
چکیده انگلیسی
The necessity of a non-invasive in-vivo test for prion diseases has become more apparent since the transmission of vCJD from the blood of a healthy individual incubating the disease. Here we show that prion urine comprises an array of protease resistant peptides, among them light chain immunoglobulin (LC). This was observed by sequencing gel bands comprising hamster urine samples, as well as by immunoblotting of similar samples with anti mouse IgG reagents for hamster samples, or with anti human IgG reagents for human samples. Our result suggests that urine samples from CJD patients can be identified by the presence of protease resistant proteins such as LC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 162, Issues 1â2, May 2005, Pages 12-18
Journal: Journal of Neuroimmunology - Volume 162, Issues 1â2, May 2005, Pages 12-18
نویسندگان
Zehavit Kariv-Inbal, Michele Halimi, Yael Dayan, Roni Engelstein, Ruth Gabizon,