کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9194656 1580508 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Restraint stress alters lung gene expression in an experimental influenza A viral infection
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Restraint stress alters lung gene expression in an experimental influenza A viral infection
چکیده انگلیسی
In the present study the global effect of restraint stress on gene expression in the murine lung during an experimental influenza A/PR8 viral infection was examined. Gene expression profiling using high density oligonucleotide microarrays revealed that the expression of 95 genes was altered on day 3 post infection (p.i.), while 48 genes were altered on day 7 p.i. Restraint stress reduced and delayed the expression of specific cytokines, cell adhesion molecules and cell surface receptors indicating alterations in cell migration to the site of infection. Furthermore, mapping of the candidate genes to known pathways revealed that genes associated with host defense and immune responses, including chemotaxis and chemokine function, antigen presentation and processing, MHC class II receptor function and inflammation were the major pathways affected by restraint stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 162, Issues 1–2, May 2005, Pages 103-111
نویسندگان
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