کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9194704 1580505 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proinflammatory cytokines and apoptosis following glutamate-induced excitotoxicity mediated by p38 MAPK in the hippocampus of neonatal rats
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Proinflammatory cytokines and apoptosis following glutamate-induced excitotoxicity mediated by p38 MAPK in the hippocampus of neonatal rats
چکیده انگلیسی
The proinflammatory cytokines TNF-α, IL-1β, and IL-6 rise during neuronal damage and activate the apoptotic mitogen-activated protein kinase p38. We studied apoptosis, the levels of TNF-α, IL-1β, and IL-6, and the cell type producing TNF-α in rats at 8, 10, and 14 days of age after neonatal exposure to glutamate, which induces neuronal damage. TNF-α production was significantly increased by glutamate, but inhibited by SB203580 (a p38 inhibitor). TNF-α, IL-1β, and IL-6 mRNA levels increased, but SB203580 did not modify their expression. Thus, the p38 signaling pathway influences the expression of inflammatory genes and its inhibition may offer anti-inflammatory therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 165, Issues 1–2, August 2005, Pages 53-62
نویسندگان
, , , , ,