Revisión de los ensayos clínicos sobre prevención del daño neurológico en el traumatismo craneoencefálico grave y análisis de su fracaso terapéutico

This paper has been divided in three parts: in the first one, we summarize the pathophysiological mecha-nisms related to SHI, targeted by the neuroprotective agents. In the second part we review the main clinical triáis carried out for SHI to date, and in the third one, we analyze the possible reasons that explain why these agents have failed to show efficacy.