MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats

These results demonstrate that combined temporary clipping of the aortic arch (just proximal to the left common carotid artery) plus left subclavian artery for 17 minutes reproduces reliable paraplegia, and a single dose of MK-801 given before ISCI provides significant neuroprotection.