کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9216764 | 1198870 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer](/preview/png/9216764.png)
چکیده انگلیسی
The sentinel lymph node (SLN) is regarded as the first tumor-draining lymph node, which may be the initial site activated by tumor antigens. To clarify the immunological functions of SLNs, a total of 89 tumor-free regional lymph nodes (41 SLNs and 48 non-SLNs) were obtained from 12 patients with oral cavity cancer, and infiltration of both DCs and NK cells was determined by immunohistochemistry. S-100+ and CD1a+ DCs infiltrated significantly into SLNs compared to non-SLNs. Analysis in each of the pN0 and pN+ patients showed that all the DC markers in pN0 patients and only S-100+ in pN+ patients were significantly more abundant in SLNs. Moreover, infiltration of CD83+ DCs was less in pN+ patients than in pN0 patients. These results suggest that more significant immune responses against cancer occur in SLNs than in non-SLNs. However the progression of disease including nodal disease may cause systemic immunosuppression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 41, Issue 1, January 2005, Pages 89-96
Journal: Oral Oncology - Volume 41, Issue 1, January 2005, Pages 89-96
نویسندگان
Koichi Sakakura, Kazuaki Chikamatsu, Tsutomu Sakurai, Katsumasa Takahashi, Takaaki Murata, Noboru Oriuchi, Nobuhiko Furuya,