کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9216838 | 1198874 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association between polymorphisms of the GPX1 gene and second primary tumours after index squamous cell cancer of the head and neck
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
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چکیده انگلیسی
We investigated the association between genetic polymorphisms in GPX1 gene amongst patients who had index squamous cell carcinoma (SCCHN) and a second primary tumour (SPT) after a primary SCCHN in a case-control study. GPX1 genotypes were determined for 61 patients with SPT and for 259 control subjects by a PCR technique using a fluorescent-labelled primer. Analysis was by an ABI automated fluorescent sequencer. The associations between specific genotypes and the development of SPT were examined by logistic regression. A significant difference was found between the control group and the SPT cases in allele frequencies of GPX1 ALAâ6 and ALAâ7 (ptrend = 0.04). These results suggest that polymorphisms in the GPX1 gene may be a marker for SPT development and further studies are indicated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 41, Issue 5, May 2005, Pages 455-461
Journal: Oral Oncology - Volume 41, Issue 5, May 2005, Pages 455-461
نویسندگان
S. Jefferies, Z. Kote-Jarai, D. Goldgar, R. Houlston, M.-J. Frazer-Williams, R. A'Hern, MPT Collaborators and R. Eeles MPT Collaborators and R. Eeles, MPT Collaborators: MPT Collaborators:, J. Henk, M. Gore, P. Rhys-Evans, D. Archer, K. Bishop,