کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9229597 | 1203314 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders
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کلمات کلیدی
NODT helper type 1PYDR genesTh1MDPNOD2APAf-1IL-1βLPSNF-κBinterleukin 1β - اینترلوکین 1βCrohn's disease - بیماری کرونTIR - تیرToll-like receptor - تیالآرnucleotide-binding oligomerization domain - دامنه oligomerization اتصال دهنده نوکلئوتیدpyrin domain - دامنه را امتحان کنیدcaspase-recruitment domain - دامنه کاریپس-استخدامBlau syndrome - سندرم بلوزapoptotic protease activating factor 1 - عامل فعال آپوپتوز پروتئاز 1nuclear factor κB - فاکتور هسته ای κBlipopolysaccharide - لیپوپلی ساکاریدCARD - کارت
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders](/preview/png/9229597.png)
چکیده انگلیسی
Pattern-recognition receptors are a first line of defense against invading pathogens. Recent advances in the understanding of innate immunity have revealed a novel family of cytosolic pattern-recognition receptors called Nods, which contain an amino-terminal effector-binding domain, a centrally located nucleotide-binding oligomerization domain (NOD) and a carboxy-terminal ligand recognition domain. Hereditary mutations of Nods have been reported in patients with certain inflammatory diseases; for example, Nod2 mutations are associated with the inflammatory granulomatous disorders, Crohn's disease and Blau syndrome. Missense mutations of Nod2 are also associated with early-onset sarcoidosis, a rare but sporadic disease. Because Nod2 is predominantly expressed in monocytes and recognizes a component of bacterial peptidoglycan, analysis of its function may help in understanding the role of the immune system in granuloma formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dermatological Science - Volume 39, Issue 2, August 2005, Pages 71-80
Journal: Journal of Dermatological Science - Volume 39, Issue 2, August 2005, Pages 71-80
نویسندگان
Naotomo Kambe, Ryuta Nishikomori, Nobuo Kanazawa,