کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9236531 | 1207469 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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![عکس صفحه اول مقاله: Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection](/preview/png/9236531.png)
چکیده انگلیسی
Lipopolysaccharide (LPS) binding protein (LBP) facilitates the transfer of LPS of Gram-negative bacteria to the pattern recognition receptor CD14, resulting in activation of immunocompetent cells. LBP can also facilitate the binding of lipoarabinomannan, a major cell wall component of mycobacteria, to immune cells. To determine the role of LBP in the immune response to pulmonary Mycobacterium tuberculosis infection, LBP gene-deficient (â/â) and normal wild-type (WT) mice were intranasally infected with M. tuberculosis. LBPâ/â mice displayed a similar survival and mycobacterial outgrowth in lungs and liver, although they demonstrated a reduced lymphocyte recruitment and activation during the early stages of infection. The clearance of pulmonary infection with the non-pathogenic M. smegmatis was also unaltered in LBPâ/â mice. These data suggest that LBP does not contribute to an effective host response in M. tuberculosis infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 116, Issue 2, August 2005, Pages 174-181
Journal: Clinical Immunology - Volume 116, Issue 2, August 2005, Pages 174-181
نویسندگان
Judith Branger, Jaklien C. Leemans, Sandrine Florquin, Peter Speelman, Douglas T. Golenbock, Tom van der Poll,