کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9236532 | 1207469 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of prolactin as a novel immunomodulator on the expression of co-stimulatory molecules and cytokine secretions on T and B human lymphocytes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We investigate the immunomodulator role of prolactin (PRL) on CD4+ and B cell activation from healthy subjects in comparison with hyperprolactinemic patients. Peripheral blood mononuclear cells, CD4+ or B cells, purified, were cultured under different conditions, as follows: with mitogen, without stimulus, with different concentrations of human PRL, with unspecific mitogen plus PRL, or with antibodies against PRL. The results revealed that PRL is produced by lymphocytes, the expression of CD69 and CD154 molecules, and interleukin secretions depend partially on the autocrine PRL, this is supported by the findings that secretions of IL-2, IFNγ, and co-stimulatory molecule expression were markedly reduced when autocrine PRL was blocked with anti-PRL antibodies. Furthermore, PRL activity was only observed during the first 2 h after activation. In contrast, B cell culture did not show any alteration by adding or blocking PRL in the expression of CD40 and CD86 in both groups: healthy subject and hyperprolactinemic patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 116, Issue 2, August 2005, Pages 182-191
Journal: Clinical Immunology - Volume 116, Issue 2, August 2005, Pages 182-191
نویسندگان
Karina Chavez-Rueda, Jesús Hérnández, Edgar Zenteno, Alfredo Leaños-Miranda, Ma Victoria Legorreta-Haquet, Francisco Blanco-Favela,