کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9236730 | 1207488 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardiac remodeling after long-term stimulation by antibodies against the α1-adrenergic receptor in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Although autoantibodies against the α1-adrenergic receptor which had been found in hypertensive patients had agonist-like activity as phenylephrine, the effects of these antibodies on cardiac remodeling have not been known. In this paper, the models with agonist-like activity of antibodies to α1-adrenergic receptor were made by immunized Wistar rats using synthesized peptides of α1A-adrenergic receptor and raised for 1 year, and the excited antibodies against the α1-adrenergic receptor which could elevate the free Ca2+ in isolated adult rat cardiomyocytes had been existed throughout the experiments after immunization. In immunized rats, despite that systolic blood pressure (SBP) had no difference with normal control, the hypertrophy of heart and cardiomyocytes was observed, the collagen deposition in heart interstitium increased, and c-jun expression and matrix metalloproteinase (MMP)-2 mRNA expression and activity in heart had increased. The results suggested that antibodies against the α1-adrenergic receptor could induce cardiac remodeling and maybe play a particular role in hypertension.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 114, Issue 2, February 2005, Pages 164-173
Journal: Clinical Immunology - Volume 114, Issue 2, February 2005, Pages 164-173
نویسندگان
Zihua Zhou, Yu-Hua Liao, Yumiao Wei, Fen Wei, Bin Wang, Liudong Li, Min Wang, Kun Liu,