کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9236734 | 1207488 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparative analysis of the fate of donor dendritic cells and B cells and their influence on alloreactive T cell responses under tacrolimus immunosuppression
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کلمات کلیدی
FCSCMTMRLEWAPCTACmAbMonoclonal antibody - آنتی بادی مونوکلونالantigen-presenting cells - آنتیژن ارائه سلولBrown Norway - براون نروژTacrolimus - تاکرولیموسchronic rejection - رد مزمنfetal calf serum - سرم گوساله جنینB cells - سلول های BDendritic cells - سلول های دندریتیکperiarteriolar lymphoid sheath - غلاف لنفوئیدی پروبیوتیکLewis - لوئیسbone marrow - مغز استخوانPALS - پالس
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We have shown that tacrolimus (TAC)-induced liver allograft acceptance is associated with migration and persistence of donor B cells and dendritic cells (DC). To clarify whether these MHC class II+ leukocytes have favorable roles in inducing tolerance, we analyzed recipient T cell reactions after allogeneic B or DC infusion. LEW rat B cells localized exclusively in BN host B cell follicles without any direct contact with host T cells. While few donor DC migrated to T cell areas and marginal zones, they were captured by host APC, suggesting that allogeneic MHC class II+ cells may induce immune reactions via the indirect pathway. Although DC-infused non-immunosuppressed recipients showed enhanced ex vivo anti-donor responses, persistent in vitro donor-specific hyporeactivity was seen equally with donor DC or B cell infusion under TAC. The results indicate that donor MHC class II+ APC are capable of regulating recipient immune reactions under TAC. Possible involvement of the indirect pathway of allorecognition is discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 114, Issue 2, February 2005, Pages 199-209
Journal: Clinical Immunology - Volume 114, Issue 2, February 2005, Pages 199-209
نویسندگان
Olga Azhipa, Kei Kimizuka, Atsunori Nakao, Hideyoshi Toyokawa, Toyokazu Okuda, Joao Seda Neto, Sean M. Alber, Takashi Kaizu, Angus W. Thomson, Anthony J. Demetris, Noriko Murase,