کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9236762 | 1207490 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia](/preview/png/9236762.png)
چکیده انگلیسی
In addition to hematopoietic progenitors, human bone marrow contains mature T/NK lymphocytes. Vα24Vβ11 NKT-cells, a subset of NK receptor+ (NKR+) T-cells in humans, are rare in bone marrow, suggesting the presence of other NKR+ T-cells which may contribute to tumor surveillance. NKR+/â T-cells were examined in blood (PB), and bone marrow from donors (DM) and patients with active hematopoietic malignancy (PM), or in remission (PR). T-cells in PR & PM were enriched for CD56+ and CD57+ subsets, compared to DM. All marrow NKR+/â T-cell subsets were more activated than PB. PM and, surprisingly, PR marrow contained more activated cells than DM. CD8+ cells were significantly increased in all patient marrows and there was evidence of the formation of an effector/memory pool in malignant marrow. These data suggest that NKR+ T-cell enrichment in human bone marrow that has been exposed to neoplastic transformation is compatible with a role in localized tumor surveillance/eradication.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 114, Issue 1, January 2005, Pages 42-51
Journal: Clinical Immunology - Volume 114, Issue 1, January 2005, Pages 42-51
نویسندگان
J. Dean, D. McCarthy, M. Lawler, D.G. Doherty, C. O'Farrelly, L. Golden-Mason,