کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9245181 | 1209942 | 2005 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Growth Hormone Inhibits Signal Transducer and Activator of Transcription 3 Activation and Reduces Disease Activity in Murine Colitis
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کلمات کلیدی
EMSASOCSTNBSLPMCGHRPCNACECSHPDSSIGFsIL-6R - SIL-6RElectrophoretic mobility shift assay - آزمون تحرک تحرک الکتروفورزSTAT - آمارProliferating Cell Nuclear Antigen - آنتیژن هسته ای تکثیر سلولیTrinitrobenzene sulfonic acid - اسید سولفونیک Trinitrobenzeneinterleukin - اینترلوکینterminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling - برچسب ترمودینامیک deoxyuridine triphosphate ترمینال deoxynucleotidyl transferase ترمینالTUNEL - تونلsuppressor of cytokine signaling - سرکوب کننده سیگنالینگ سیتوکینlamina propria mononuclear cell - سلول تک هسته ای لامین پروپریاdextran sodium sulfate - سولفات سدیم سدیمFas Ligand - فاس لیگاندFasL - فاسدInsulin-like growth factor - فاکتور رشد مانند انسولینSignal transducer and activator of transcription - مبدل سیگنال و فعال کننده رونویسیwild type - نوع وحشیGrowth hormone - هورمون رشدpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازGlycoprotein - گلیکوپروتئینSoluble IL-6 receptor - گیرنده حلقوی IL-6growth hormone receptor - گیرنده هورمون رشد
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Constitutive signal transducer and activator of transcription (STAT) 3 activation promotes chronic inflammation and epithelial proliferation in murine colitis and human inflammatory bowel disease. SHP-2, through binding to the glycoprotein 130 signaling receptor, negatively regulates STAT3 activation. Growth hormone reduces disease activity and promotes mucosal healing in colitis and can activate SHP-2. Methods: We hypothesized that growth hormone administration would reduce disease activity in experimental colitis and that this would involve modulation of SHP-2/glycoprotein 130 association and STAT3 activation. Results: Growth hormone administration improved weight gain and colon histology in interleukin 10-null mice with colitis. Growth hormone reduced apoptosis and increased proliferation of crypt epithelial cells while increasing apoptosis of lamina propria mononuclear cells. Growth hormone increased SHP-2/glycoprotein 130 association and reduced colonic STAT3 activation in interleukin 10-null mice and in biopsy samples from patients with Crohn's colitis. Expression of the antiapoptotic protein bcl-2 was increased in crypt epithelial cells after growth hormone treatment. Growth hormone increased SHP-2/glycoprotein 130 binding and reduced interleukin 6-dependent STAT3 activation in the T84 human colon carcinoma and Jurkat human T-cell leukemia lines. Conclusions: Growth hormone administration improves weight gain and reduces disease activity in interleukin 10-null mice with colitis. The improvement in disease activity is associated with increased SHP-2/glycoprotein 130 binding and reduced STAT3 activation in both murine and Crohn's colitis. Growth hormone may be a useful therapy in inflammatory bowel disease, in terms of both improving anabolic metabolism and enhancing mucosal healing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 129, Issue 1, July 2005, Pages 185-203
Journal: Gastroenterology - Volume 129, Issue 1, July 2005, Pages 185-203
نویسندگان
Xiaonan Han, Danuta Sosnowska, Erin L. Bonkowski, Lee A. Denson,