کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
925049 921300 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An experimental approach to detecting dementia in Down syndrome: A paradigm for Alzheimer’s disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
An experimental approach to detecting dementia in Down syndrome: A paradigm for Alzheimer’s disease
چکیده انگلیسی

Measures developed from animal models of aging may detect dementia of the Alzheimer’s type in a population at-risk for Alzheimer’s disease (AD). Although, by middle age, individuals with Down syndrome (DS) show an extraordinarily high prevalence of AD-type pathology, their severe idiopathic cognitive deficits tend to confound the clinical diagnosis of AD. The current study was designed to improve detection of AD in DS by using measures of learning and memory derived from animal models of aging. Adults with DS (N = 34) were assessed and reassessed (n = 19) approximately one year later using stimulus–response (S–R) test methods derived from experimental literature, as well as standardized informant-based tests. Results demonstrated high validity and reliability of select tests. The implication of early symptom detection in a population at-risk for AD-type dementia was discussed in terms of potential brain regions of interest.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Cognition - Volume 64, Issue 1, June 2007, Pages 92–103
نویسندگان
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