کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9261554 | 1214305 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Avidity of anti-beta-2-glycoprotein I antibodies
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The terms affinity and avidity are often used indiscriminately, despite clearly differing. Since affinity refers to monovalent binding of antibodies to a monovalent epitope, the majority of data on the binding of anti-β2-glycoprotein I antibodies (anti-β2-GPI) characterized their avidity rather than affinity. Anti-β2-GPI were generally believed to be of low avidity, but heterogeneous avidity of patients' IgG anti-β2-GPI has been demonstrated. High avidity anti-β2-GPI monoclonals were reported to possess higher pathogenicity than low avidity anti-β2-GPI. Polyclonal high avidity anti-β2-GPI were found to be more common in patients with antiphospholipid syndrome (APS) and associated with thrombosis. Some conformational changes of β2-GPI are required for the binding of polyclonal anti-β2-GPI to the antigen: neither high density of the antigen nor high avidity of the anti-β2-GPI alone is sufficient for the recognition. Avidity of anti-β2-GPI should be considered in any attempt of inter-laboratory standardisation and/or evaluation of anti-β2-GPI enzyme-linked immunosorbent assay (ELISA).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 4, Issue 5, June 2005, Pages 303-308
Journal: Autoimmunity Reviews - Volume 4, Issue 5, June 2005, Pages 303-308
نویسندگان
B. BožiÄ, S. ÄuÄnik, T. Kveder, B. Rozman,