کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9264192 | 1216473 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of ELISA-Detected Anti-HLA Antibodies on Pediatric Cardiac Allograft Outcome
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کلمات کلیدی
EMBPRApanel-reactive antibody - آنتی بادی واکنش پانلHLA human leukocyte antigen - آنتی ژن HLA لوکوسیتی انسانHuman leukocyte antigen - آنتی ژن لوسکسی انسانHLA - آنتیژن گلبول سفید انسانیcoronary artery disease - بیماری عروق کرونرendomyocardial biopsies - بیوپسی آندومیاکاردیAcute rejection - رد حادCAD - طراحی به کمک رایانه یا کَد
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Impact of ELISA-Detected Anti-HLA Antibodies on Pediatric Cardiac Allograft Outcome Impact of ELISA-Detected Anti-HLA Antibodies on Pediatric Cardiac Allograft Outcome](/preview/png/9264192.png)
چکیده انگلیسی
In this study, we determine whether the presence of enzyme-linked immunosorbent assay (ELISA) detected anti-human leukocyte antigen (HLA) antibodies correlates with acute and chronic rejection in pediatric heart transplantation (Tx). Forty-five patients, who had serial ELISA pre- and posttransplantation, were studied. Age at Tx was 8.2 ± 7.2 years. Acute rejection (AR) was defined as International Society for Heart and Lung Transplantation Grade â¥3a. Patients were defined as rejectors (22 cases) if they had recurrent AR or steroid-resistant AR within the first year post-Tx; the other cases (23) were defined as nonrejectors. Overall, 219 samples were analyzed. Twenty-two of the 45 had pre- or post-Tx anti-HLA antibodies: 77% in rejectors (17/22) and only 22% in nonrejectors (5/23), p = 0.0002. Pre-Tx HLA antibodies were present in 12 cases (27%). Presensitization was more frequent in rejectors (11/22, 50%) than in nonrejectors (1/23, 4%, p = 0.0005). Nineteen cases retained (9 cases) or developed (10 cases) anti-HLA antibodies post-Tx: 14 in rejectors (63.6%) and 5 in nonrejectors (21.7%), p = 0.003. Four of eight cases with coronary artery disease (50%) had preformed anti-HLA antibodies compared with 8 of 37 without coronary artery disease (25.6%) (p = 0.09). Preformed, persistent, and de novo ELISA-detected anti-HLA antibodies were correlated with first-year acute rejection profile.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 66, Issue 5, May 2005, Pages 513-518
Journal: Human Immunology - Volume 66, Issue 5, May 2005, Pages 513-518
نویسندگان
Sylvie Di Filippo, Alin Girnita, Steven A. Webber, Sabrina Tsao, Gerard J. Boyle, Susan A. Miller, Sanjiv K. Gandhi, Adriana Zeevi,