Plasmodium falciparum malaria in south-west Nigerian children: Is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria?

In conclusion, these results suggest that genetic polymorphisms at host adhesion molecules loci are an important variable in the susceptibility to severe malaria. Further studies of host loci are needed to further delineate which polymorphisms are associated with severe malaria and increase our knowledge of the biology of host-parasite interactions.