کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9275950 1222362 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The genetics of staphylococcal biofilm formation-will a greater understanding of pathogenesis lead to better management of device-related infection?
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
The genetics of staphylococcal biofilm formation-will a greater understanding of pathogenesis lead to better management of device-related infection?
چکیده انگلیسی
Staphylococcus epidermidis and Staphylococcus aureus are common causes of biofilm-mediated prosthetic device-related infection. The polysaccharide adhesion mechanism encoded by the ica operon is currently the best understood mediator of biofilm development, and represents an important virulence determinant. More recently, the contributions of other virulence regulators, including the global regulators agr, sarA and σB, to the biofilm phenotype have also been investigated. Nevertheless, little has changed at the bedside; the clinical and laboratory diagnosis of device-related infection can be difficult, and biofilm resistance frequently results in failure of therapy. This review assesses the way in which advances in the understanding of biofilm genetics may impact on the clinical management of device-related infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 11, Issue 12, December 2005, Pages 967-973
نویسندگان
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