کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9278671 1222958 2005 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
How radiation kills cells: Survival of Deinococcus radiodurans and Shewanella oneidensis under oxidative stress
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
How radiation kills cells: Survival of Deinococcus radiodurans and Shewanella oneidensis under oxidative stress
چکیده انگلیسی
We have recently shown that Deinococcus radiodurans and other radiation resistant bacteria accumulate exceptionally high intracellular manganese and low iron levels. In comparison, the dissimilatory metal-reducing bacterium Shewanella oneidensis accumulates Fe but not Mn and is extremely sensitive to radiation. We have proposed that for Fe-rich, Mn-poor cells killed at radiation doses which cause very little DNA damage, cell death might be induced by the release of Fe(II) from proteins during irradiation, leading to additional cellular damage by Fe(II)-dependent oxidative stress. In contrast, Mn(II) ions concentrated in D. radiodurans might serve as antioxidants that reinforce enzymic systems which defend against oxidative stress during recovery. We extend our hypothesis here to include consideration of respiration, tricarboxylic acid cycle activity, peptide transport and metal reduction, which together with Mn(II) transport represent potential new targets to control recovery from radiation injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEMS Microbiology Reviews - Volume 29, Issue 2, April 2005, Pages 361-375
نویسندگان
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