کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9283847 | 1225212 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Absence of complement receptor 3 results in reduced binding and ingestion of Mycobacterium tuberculosis but has no significant effect on the induction of reactive oxygen and nitrogen intermediates or on the survival of the bacteria in resident and interfe
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We show that, although CR3 plays a role in the uptake of viable Mtb, the receptor plays no role in the subsequent survival of the bacteria. The finding holds true for resident MÏs and for interferon-gamma (IFN-γ) activated MÏs, both in the absence and presence of serum opsonins. Activation of MÏ populations with IFN-γ significantly inhibits the growth of Mtb in host MÏs and enhances the production of ROI and RNI. However, the presence of CR3 was not critical in any of these mechanisms. Furthermore, we demonstrate that the control of intracellular growth of Mtb in IFN-γ activated MÏs is not mediated by a direct effect of RNI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 39, Issue 3, September 2005, Pages 57-67
Journal: Microbial Pathogenesis - Volume 39, Issue 3, September 2005, Pages 57-67
نویسندگان
Amanda W.J. Rooyakkers, Richard W. Stokes,