کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9283957 | 1225231 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunopathogenesis of infection with the visceralizing Leishmania species
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کلمات کلیدی
PBMCLPGIL-2RPPGPKDLMZMTGF-βtransforming growth factor-β - تبدیل فاکتور رشد βPeripheral blood mononuclear cell - سلول تک هسته ای خون محیطیDendritic cell - سلول دندریتیکperiarteriolar lymphoid sheath - غلاف لنفوئیدی پروبیوتیکLipophosphoglycan - لیپوفسفوگلیکانPALS - پالسInterleukin 2 receptor - گیرنده اینترلوکین 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
This review focuses on host responses to infection with the species that cause visceral leishmaniasis, as they contrast with species causing localized cutaneous leishmaniasis. Data from experimental models document significant differences between host responses to organisms causing these diverse syndromes. The visceralizing Leishmania spp. cause localized organ-specific immune responses that are important determinants of disease outcome. Both the Leishmania species causing cutaneous and those causing visceral leishmaniasis require a Type 1 immune response to undergo cure in mouse models. However, during progressive murine infection with the visceralizing Leishmania sp., the Type 1 response is suppressed at least in part by TGF-β and IL-10 without type 2 cytokine production. This contrasts with the cutaneous species L. major, in which a Type 2 response suppresses type 1 cytokines and leads to murine disease progression. Population and family studies are beginning to elucidate human genetic determinants predisposing to different outcomes of Leishmania infection. These studies should eventually result in a better understanding of the immunopathogenesis and the spectrum of human leishmaniasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 38, Issue 4, April 2005, Pages 147-160
Journal: Microbial Pathogenesis - Volume 38, Issue 4, April 2005, Pages 147-160
نویسندگان
Mary E. Wilson, Selma M.B. Jeronimo, Richard D. Pearson,