کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9286645 | 1227350 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HPV16, HPV18, and HIV infection may influence cervical cytokine intralesional levels
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: HPV16, HPV18, and HIV infection may influence cervical cytokine intralesional levels HPV16, HPV18, and HIV infection may influence cervical cytokine intralesional levels](/preview/png/9286645.png)
چکیده انگلیسی
Infection with oncogenic human papillomavirus (HPV) is considered to be the major risk to cervical cancer. This study analyzed the influence of HPV infection on cytokine intralesional levels in cervical lesion in the presence or not of HIV infection. Cervical biopsies from 42 women were studied. HPV detection and typing were performed using amplified DNA hybridized with sequence-specific primers, and cytokine intralesional levels were detected using ELISA. HPV16+ biopsies exhibited increased IFN-γ and IL-10 when compared to HPV16â (P = 0.03 and 0.04, respectively). HPV18+ biopsies exhibited decreased TNF-α (P = 0.009) and IFN- γ (P = 0.01) when compared to HPV18â. In accordance to HIV status, HIVâ/HPV16+ patients exhibited increased IFN-γ when compared to those presenting HIVâ/HPV16â (P = 0.007). HIVâ/HPV18+ patients presented decreased IFN-γ when compared to HIVâ/HPV18â (P = 0.02). These results suggest that the presence of HPV16 infection may influence cervical lesion installation, and irrespective of HIV status, HPV18 infection may be more aggressive than HPV-16.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 334, Issue 2, 10 April 2005, Pages 294-298
Journal: Virology - Volume 334, Issue 2, 10 April 2005, Pages 294-298
نویسندگان
Ana Paula M. Fernandes, Maria Alice G. Gonçalves, Geraldo Duarte, Fernando Q. Cunha, Renata T. Simões, Eduardo A. Donadi,