کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9286750 | 1227368 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induction of active immune suppression by co-immunization with DNA- and protein-based vaccines
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کلمات کلیدی
IL-10DTHHprtFMDVCSFVMTT - MTTAdoptive transfer - انتقال واجبdelayed-type hypersensitivity - تاخیر نوع حساسیت بالاSuppression - سرکوبT cells - سلول های تیCo-administration - همکاری ادارهhypoxanthine phosphoribosyl transferase - هیپوکسانتین فسفریبوسیل ترانسفرازDNA vaccination - واکسیناسیون DNAFoot and mouth disease virus - ویروس بیماری پا و دهان
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Although immunization has been used for eliciting immune response, here we show that it can also induce immune suppression. When a DNA vaccine encoding a viral antigen such as the VP1 protein from the foot and mouth disease virus is administered together with its recombinant protein antigen or a viral preparation containing the same antigen, the immunized animals developed significantly reduced antigen-specific T cell-mediated responses and became impaired to subsequent rechallenge with the same antigen. The induction of immune suppression is mediated by suppressor T cells, as demonstrated by an adoptive transfer experiment and mixed lymphocyte reactions. The induction of immune suppression in immunized animals is also correlated with a shift of cytokine balance, as reflected by an elevated level of IL-10 and reduced level of IFN-γ or IL-2. Hence, co-immunization with DNA- and protein-based vaccines may represent a novel means for inducing active suppression against untoward immunity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 337, Issue 1, 20 June 2005, Pages 183-191
Journal: Virology - Volume 337, Issue 1, 20 June 2005, Pages 183-191
نویسندگان
Huali Jin, Youmin Kang, Guoxing Zheng, Qifa Xie, Chong Xiao, Xinyu Zhang, Yang Yu, Kaichun Zhu, Gan Zhao, Fuchun Zhang, Aoshuang Chen, Bin Wang,