کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9287971 | 1227447 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Detection of amantadine-resistant variants among avian influenza viruses isolated in North America and Asia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Detection of amantadine-resistant variants among avian influenza viruses isolated in North America and Asia Detection of amantadine-resistant variants among avian influenza viruses isolated in North America and Asia](/preview/png/9287971.png)
چکیده انگلیسی
Here, we report the diversity of amantadine-resistant mutants among avian influenza A viruses with pandemic potential (H5, H6, H7, and H9 hemagglutinin subtypes). Drug-resistant variants were not detected among 1979-83 isolates, whereas 31.1% of H5 and 10.6% of H9 strains from Southeast Asia isolated in 2000-04 carried mutations in M2 protein. In North America, resistant variants occurred among H7 viruses only (16.4% of those tested). H6 viruses were amantadine-sensitive. These findings prompt concern regarding the control of pandemic influenza, the possibility that the next pandemic virus will be amantadine-resistant and the need to monitor the use of the drug in poultry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 341, Issue 1, 10 October 2005, Pages 102-106
Journal: Virology - Volume 341, Issue 1, 10 October 2005, Pages 102-106
نویسندگان
Natalia A. Ilyushina, Elena A. Govorkova, Robert G. Webster,