کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9296451 | 1233533 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinical evaluation of urinary excretion of liver-type fatty acid-binding protein as a marker for the monitoring of chronic kidney disease: A multicenter trial
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کلمات کلیدی
CCRROCFFANAGH-FABPFABPL-FABPN-acetyl-β-d-glucosaminidase - N-acetyl-β-d-glycosaminidaseFree fatty acid - اسید چرب آزادchronic kidney disease - بیماری مزمن کلیویELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاBody-mass index - شاخص توده بدنBMI - شاخص توده بدنیnot significant - مهم نیستCKD - نارسایی مزمن کلیهreceiver-operator characteristic - ویژگی گیرنده-اپراتورFatty acid-binding protein - پروتئین اتصال دهنده اسید چربheart-type fatty acid-binding protein - پروتئین اتصال دهنده اسید چرب قلب نوعliver-type fatty acid-binding protein - پروتئین متصل به اسید چرب کبدcreatinine - کراتینینCreatinine clearance - کلیرانس کراتینین
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
To confirm the clinical usefulness of the measurement of urinary liver-type fatty acid-binding protein (L-FABP) in chronic kidney disease (CKD), we carried out a multicenter trial. Clinical markers were measured in patients with nondiabetic CKD (n = 48) every 1 to 2 months for a year. We divided patients retrospectively into progression (n = 32) and nonprogression (n = 16) groups on the basis of the rate of disease progression, then assessed several clinical markers. Initially creatinine clearance (Ccr) was similar in the 2 groups; however, the urinary L-FABP level was significantly higher in the former group than in the latter (111.5 vs 53 μg/g creatinine, P < .001). For the monitoring CKD, we set the cutoff values for urinary L-FABP and urinary protein at 17.4 μg/g creatinine and 1.0 g/g creatinine, respectively. Urinary L-FABP was more sensitive than urinary protein in predicting the progression of CKD (93.8% and 68.8%, respectively). However, urinary protein showed greater specificity than did urinary L-FABP (93.8% and 62.5%, respectively). Over time, the progression of CKD tended to correlate with changes in urinary L-FABP (r = â .32, P < .05), but not in urinary protein (r = .18, not significant). The dynamics of urinary protein differed from that of urinary L-FABP, which increased as Ccr declined. Urinary L-FABP is more sensitive than urinary protein in predicting the progression of CKD. Urinary excretion of L-FABP increases with the deterioration of kidney function. Urinary L-FABP is therefore a useful clinical marker in the monitoring of CKD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 3, March 2005, Pages 125-133
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 3, March 2005, Pages 125-133
نویسندگان
Atsuko Kamijo, Takeshi Sugaya, Akihisa Hikawa, Masaya Yamanouchi, Yasunobu Hirata, Toshihiko Ishimitsu, Atsushi Numabe, Masao Takagi, Hiroshi Hayakawa, Fumiko Tabei, Tokuichiro Sugimoto, Naofumi Mise, Kenjiro Kimura,