کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9296468 | 1233534 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Idiopathic intracranial hypertension, polycystic-ovary syndrome, and thrombophilia
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کلمات کلیدی
IIHethylenediaminetetracetateResistance to activated protein CPTGdRVVTMTHFRPCOSLPADHEASAPTTHRTAcla - آلاAnticardiolipin antibody - آنتی بادی anticardiolipinEDTA - اتیلن دی آمین تترا استیک اسید activated partial thromboplastin time - زمان ترومبوپلاستین جزئی فعال شده استdehydroepiandrosterone sulfate - سولفات dehydroepiandrosteroneBMI - شاخص توده بدنیPlasminogen activator inhibitor activity - فعالیت مهارکننده فعال کننده پلاسمینوژنLipoprotein a - لیپوپروتئین aCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیhormone-replacement therapy - هورمون جایگزین درمانpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازidiopathic intracranial hypertension - پرفشاری خون داخل قاعدگی idiopathic
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Idiopathic intracranial hypertension, polycystic-ovary syndrome, and thrombophilia Idiopathic intracranial hypertension, polycystic-ovary syndrome, and thrombophilia](/preview/png/9296468.png)
چکیده انگلیسی
We studied thrombophilia, hypofibrinolysis, and polycystic-ovary syndrome (PCOS) in 65 women consecutively referred because of idiopathic intracranial hypertension (IIH) as a means of better understanding the origin of IIH, with the ultimate goal of developing novel medical therapies for IIH. Our hypothesis: IIH results in part from inadequate drainage of cerebrospinal fluid (CSF) resulting from thrombotic obstruction to CSF resorption-outflow, favored by thrombophilia-hypofibrinolysis. We conducted the polymerase chain reaction (PCR) and assessed serologic coagulation measures in 65 women (64 of them white) with IIH, PCR in 102 healthy white female controls (72 children, 30 age-matched adults), and serologic measures in the 30 adults. Of the 65 patients, 37 (57%) were found to have PCOS; 16 (43%) were obese (BMI ⥠30 to < 40), and 19 (51%) were extremely obese (BMI ⥠40). Of the 65 women with IIH, 25 (38%) were homozygous for the thrombophilic C677T MTHFR mutation, compared with 14% of controls (14/102) (P = .0002). Thrombophilic high concentrations of factor VIII (>150%) were present in 9 of 65 (14%) IIH cases, compared with 0 of 30 controls (0%) (Fisher's p [pf] = .053). An increased concentration of lipoprotein A (⥠35 mg/dL), associated with hypofibrinolysis, was present in 19 of 65 IIH cases (29%), compared with 3 of 30 controls (10%) (pf = .039). IIH occurred in 18 of 65 IIH patients taking estrogen-progestin contraceptives (28%), in 6 patients taking hormone-replacement therapy (9%), and in 5 pregnant subjects (8%). We speculate that PCOS, associated with obesity and extreme obesity, is a treatable promoter of IIH. We also speculate that if thrombophilia-hypofibrinolysis and subsequent thrombosis are associated with reduced CSF resorption in the arachnoid villi of the brain, thrombophilia and hypofibrinolysis-often exacerbated by thrombophilic exogenous estrogens, pregnancy, or the paradoxical hyperestrogenemia of PCOS-are treatable promoters of IIH.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 2, February 2005, Pages 72-82
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 2, February 2005, Pages 72-82
نویسندگان
Charles J. Glueck, Dawit Aregawi, Naila Goldenberg, Karl C. Golnik, Luann Sieve, Ping Wang,