کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9296518 | 1233537 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Time-dependent changes in plasma osteopontin levels in patients with anterior-wall acute myocardial infarction after successful reperfusion: Correlation with left-ventricular volume and function
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کلمات کلیدی
ECMTGF-βCK-MBhsCRPmRNAMMPAmI - AMIAUC - AUCmessenger RNA - RNA messengerleft ventricle - بطن چپtransforming growth factor-β - تبدیل فاکتور رشد βanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceAcute myocardial infarction - سکته قلبیExtracellular matrix - ماتریکس خارج سلولیmatrix metalloproteinase - ماتریکس متالوپروتئینازarea under the curve - منطقه تحت منحنیhigh-sensitivity C-reactive protein - پروتئین واکنش پذیر با حساسیت بالا CCreatine kinase - کراتین کینازcreatine kinase-MB - کراتین کیناز MB
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Osteopontin is a secreted extracellular-matrix glycoprotein that plays a role in the healing of remodeling tissue. We examined the relationship of plasma osteopontin levels with left-ventricular (LV) volume and function in 18 consecutive patients who underwent successful reperfusion after anterior-wall acute myocardial infarction (AMI). The plasma osteopontin level was within the control range at admission (mean ± SD 420 ± 195 ng/mL), began to increase on day 2 (935 ± 464 ng/mL), and reached a maximum around day 3 (1139 ± 482 ng/mL). The level remained high on days 4, 5, and 7 (â¼1000 ng/mL) and then decreased on day 14. Maximal plasma osteopontin levels and the difference between maximal and minimal levels were positively correlated with LV end-systolic volume index (r = .58, P < .05; and r = .65, P < .01, respectively) and negatively correlated with LV ejection fraction (r = â.52, P < .05; and r = â.60, P < .01, respectively). The area under the curve of plasma osteopontin levels for 14 days after AMI was significantly correlated with LV end-systolic volume index (r = .66, P < .01), LV end-diastolic volume index (r = .50, P < .05), and LV ejection fraction (r = â.55, P < .05). In subgroup patients with the same area of risk for myocardial infarction (ie, responsible lesions located at the same proximal left anterior descending coronary artery), essentially the same or a closer relationship between plasma osteopontin level and LV volume and function was noted. Plasma osteopontin levels were correlated substantially with plasma levels of high-sensitivity C-reactive protein (hsCRP) and weakly with serum creatine kinase release. In conclusion, the plasma level of osteopontin changes in a time-dependent fashion and is correlated with LV volumes and function and associated substantially with the extent of the inflammatory response indicated by the plasma hsCRP level and weakly with infarct size estimated on the basis of cardiac-enzyme release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 1, January 2005, Pages 33-40
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 1, January 2005, Pages 33-40
نویسندگان
Chisato Suezawa, Shozo Kusachi, Takashi Murakami, Kenichi Toeda, Satoshi Hirohata, Keigo Nakamura, Keizo Yamamoto, Kazuya Koten, Toru Miyoshi, Yasushi Shiratori,