کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
930241 1474450 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes in resting connectivity during recovery from severe traumatic brain injury
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Changes in resting connectivity during recovery from severe traumatic brain injury
چکیده انگلیسی

In the present study we investigate neural network changes after moderate and severe traumatic brain injury (TBI) through the use of resting state functional connectivity (RSFC) methods. Using blood oxygen level dependent functional MRI, we examined RSFC at 3 and 6 months following resolution of posttraumatic amnesia. The goal of this study was to examine how regional off-task connectivity changes during a critical period of recovery from significant neurological disruption. This was achieved by examining regional changes in the intrinsic, or “resting”, BOLD fMRI signal in separate networks: 1) regions linked to goal-directed (or external-state) networks and 2) default mode (or internal-state) networks. Findings here demonstrate significantly increased resting connectivity internal-state networks in the TBI sample during the first 6 months following recovery. The most consistent finding was increased connectivity in both internal and external state networks to the insula and medial temporal regions during recovery. These findings were dissociable from repeat measurements in a matched healthy control sample.


► Resting brain connectivity was examined during recovery from brain injury.
► Results reveal changes between “internal” and “goal-directed” networks during recovery.
► The most consistent finding was increased connectivity within the insula.
► Insula connectivity may permit fluid negotiation between internal states and external demands.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Psychophysiology - Volume 82, Issue 1, October 2011, Pages 115–123
نویسندگان
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