Cystine and glutamate transport in renal epithelial cells transfected with human system x-c

Our findings indicate that stable transfection of MDCK cells with xCT and 4F2hc results in a cell-line expressing a functional system x-c transporter that can utilize L-cystine and L-glutamate as substrates. This study apparently represents the first stable transfection of a mammalian cell line with system x-c.