کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9319141 | 1599487 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel Experimental Therapeutic Approaches for Prostate Cancer
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کلمات کلیدی
ASOHRPCAntisense oligodeoxynucleotide - oligodeoxynucleotide antisensesiRNA - siRNAChimeric antibodies - آنتیبادیهای کرومیکAntisense - آنتیسنسsmall interference RNA - تداخل کوچک RNAApoptosis - خزان یاختهایRISC - خطرProstate cancer - سرطان پروستاتHormone refractory prostate cancer - سرطان پروستات مقاوم به هورمون استProdrug - پروتئینAndrogen Receptor - گیرنده آندروژنی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Early detection and aggressive treatment of early prostate cancer resulted in a significant decline of overall mortality rates. However, the treatment of advanced tumor stages still represents a crucial problem. Knowledge on molecular alterations taking place in the development and progression of prostate cancer increased rapidly in the past few years, thanks also to the use of novel techniques that enabled to perform broad gene expression profiling of tumors. This better understanding of the molecular biology of prostate cancer led to the establishment of novel strategies to delay/inhibit tumor progression. This review summarizes some recent therapeutic approaches including the specific blockade of androgen receptor signaling as well as of other intracellular signal transduction pathways such as the EGF signaling pathway, some interesting strategies that aim to promote apoptosis or differentiation, or to inhibit proliferation of prostate tumor cells and some novel studies on drugs which interfere with the vasculature of prostate tumors in order to block their nutritional supply.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EAU Update Series - Volume 3, Issue 4, December 2005, Pages 227-239
Journal: EAU Update Series - Volume 3, Issue 4, December 2005, Pages 227-239
نویسندگان
Ilaria T.R. Cavarretta, Zoran Culig, Helmut Klocker, Iris E. Eder,