کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9341584 | 1261227 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of albumin as a fatty acid carrier for biosynthesis of lens lipids
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی و میکروب شناسی (عمومی)
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چکیده انگلیسی
Although serum albumin is the major protein component of the aqueous humor and vitreous humor, its possible physiological role(s) in lens metabolism has not yet been determined. BODIPY fatty acid, a fluorescent analogue of a C12 long chain fatty acid, was bound to serum albumin, then incubated with lenses in culture. After various times of incubation, the lenses were homogenized, lipids extracted, and the extracted lipids resolved by thin layer chromatography. Fluorescence analyses demonstrated that the BODIPY fatty acid-albumin complex was translocated into the lens, where the BODIPY fatty acid was incorporated in a time dependent manner into numerous lipids, including phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin. Together, the results strongly suggest that serum albumin in the aqueous humor and/or vitreous humor facilitates the translocation of long chain fatty acids into the lens, where they are used for the biosynthesis of lens lipids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 80, Issue 1, January 2005, Pages 31-36
Journal: Experimental Eye Research - Volume 80, Issue 1, January 2005, Pages 31-36
نویسندگان
J. Sabah, E. McConkey, R. Welti, K. Albin, L.J. Takemoto,