کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
936610 | 1475169 | 2013 | 8 صفحه PDF | دانلود رایگان |

• DA impairs appetitive long term memory consolidation in honey bees.
• DA antagonist improves appetitive memory.
• Results reveal a dopaminergic tonic modulation of appetitive memory.
Studies in vertebrates and invertebrates have proved the instructive role that different biogenic amines play in the neural representation of rewards and punishments during associative learning. Results from diverse arthropods and using different learning paradigms initially agreed that dopamine (DA) is needed for aversive learning and octopamine (OA) is needed for appetitive learning. However, the notion that both amines constitute separate pathways for appetitive and aversive learning is changing. Here, we asked whether DA, so far only involved in aversive memory formation in honey bees, does also modulate appetitive memory. Using the well characterized appetitive olfactory conditioning of the proboscis extension reflex (PER), we show that DA impairs appetitive memory consolidation. In addition, we found that blocking DA receptors enhances appetitive memory. These results are consistent with the view that aversive and appetitive components interact during learning and memory formation to ensure adaptive behavior.
Journal: Neurobiology of Learning and Memory - Volume 106, November 2013, Pages 230–237