کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9366806 1271949 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lysophospholipides et cancer : état des lieux et perspectives
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Lysophospholipides et cancer : état des lieux et perspectives
چکیده انگلیسی
Circulating phospholipids carrying a single esterified fatty acid, the so-called lysophospholipids, are now considered as mediators of the intercellular communication. Their major members are the lysophosphatidic acid and the sphingosine 1-phosphate, two molecules displaying biological activities similar to those of growth factors or cytokines, through a recently identified subfamily of G protein-coupled receptors. They are involved in various biological processes, e.g., brain development and angiogenesis, but the following evidences suggest that these lipids are also significant actors of tumour development: (i) they stimulate the growth, survival and migration of tumour cells from various origins (ovary, prostate, glioblastoma…); (ii) they are abundant in malignant effusions; (iii) the lysophospholipid-producing enzymes are tumourigenic. Even if it remains necessary to define the role of these “oncolipids” in relationship with oncogenes and tumor suppressors, they may well be the mediators of an efficient autostimulatory system of the proliferating and migratory capacities of cancer cells, suggesting that lysophospholipids could represent novel valuable targets for anticancer pharmacology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathologie Biologie - Volume 53, Issue 1, January 2005, Pages 57-62
نویسندگان
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