کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
936968 1475210 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
BDNF reverses the CTA memory deficits produced by inhibition of protein synthesis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
BDNF reverses the CTA memory deficits produced by inhibition of protein synthesis
چکیده انگلیسی

Brain-derived neurotrophic factor (BDNF) is an essential protein synthesis product that has emerged as one of the most potent molecular mediators of not only central synaptic plasticity, but also behavioral interactions between an organism and its environment. Our previous studies on the insular cortex (IC), a region of the temporal cortex implicated in the acquisition and storage of conditioned taste aversion (CTA), have demonstrated that intracortical microinfusion of BDNF induces a lasting potentiation of synaptic efficacy in the projection from the basolateral nucleus of the amygdala (Bla) to the IC of adult rats in vivo. Recently, we found that intracortical microinfusion of BDNF previous to CTA training enhances the retention of this task. In this work, we present experimental data showing that acute intracortical delivery of BDNF (2 μg/2 μl per side) reverses the deficit in CTA memory caused by inhibition of insular cortex protein synthesis due to anisomycin administration (100 μg/μl per side) in male adult Wistar rats. These findings suggest that BDNF is a protein synthesis product essential for neocortical long-term memory storage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 90, Issue 3, October 2008, Pages 584–587
نویسندگان
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