کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
937482 924496 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Advances in functional neuroanatomy: A review of combined DTI and fMRI studies in healthy younger and older adults
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Advances in functional neuroanatomy: A review of combined DTI and fMRI studies in healthy younger and older adults
چکیده انگلیسی


• It is hypothesized that structural connectivity influences neural processing.
• We reviewed studies that combined DTI and fMRI in younger and older adults.
• Results revealed that DTI integrity–fMRI activity relationships varied with aging.
• DTI integrity–fMRI activity relationships also varied with neural measure proximity.
• These findings have implications for current neurocognitive aging theories.

Structural connections between brain regions are thought to influence neural processing within those regions. It follows that alterations to the quality of structural connections should influence the magnitude of neural activity. The quality of structural connections may also be expected to differentially influence activity in directly versus indirectly connected brain regions. To test these predictions, we reviewed studies that combined diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) in younger and older adults. By surveying studies that examined relationships between DTI measures of white matter integrity and fMRI measures of neural activity, we identified variables that accounted for variability in these relationships. Results revealed that relationships between white matter integrity and neural activity varied with (1) aging (i.e., positive and negative DTI–fMRI relationships in younger and older adults, respectively) and (2) spatial proximity of the neural measures (i.e., positive and negative DTI–fMRI relationships when neural measures were extracted from adjacent and non-adjacent brain regions, respectively). Together, the studies reviewed here provided support for both of our predictions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 37, Issue 7, August 2013, Pages 1201–1210
نویسندگان
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