کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9415872 | 1292947 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduced suppression of CO2-induced ventilatory stimulation by endomorphins relative to morphine
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کلمات کلیدی
MORNLXNaloxone hydrochlorideHCVREM2EM1DAMGO - DREAMOpioid - opioidOpioids: anatomy, physiology, and behavior - Opioids: آناتومی، فیزیولوژی و رفتارendomorphin-2 - آندومورفین 2Neurotransmitters, Modulators, Transporters, and Receptors - انتقال دهنده های عصبی، مدولاتورها، حمل کننده ها و گیرنده هاendomorphin-1 - اندومورفین 1Frequency - بسامد یا فرکانسRespiration - تنفسVentilation - تهویه minute ventilation - تهویه ده دقیقهTidal volume - حجم نزولیmorphine sulfate - مورفین سولفاتHypercapnia - هیپرکاپنهHypercapnic ventilatory response - واکنش هوای فشردهControl of breathing - کنترل تنفسmu-opioid receptor - گیرنده ی مئو-اپوئیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Opioids are among the most effective analgesics, but a major limitation for their therapeutic usefulness is their induction of respiratory depression. Endomorphin-1 (EM1), in contrast to several other mu opioids, exhibits a threshold for respiratory depression that is well above its threshold for analgesia. Its effect on sensitivity to CO2, however, remains unknown. Minute ventilation (VE) in 2, 4, and 6% CO2 was measured before and after systemic administration of EM1, endomorphin-2 (EM2), DAMGO, and morphine in the conscious rat. EM1 and EM2 attenuated the hypercapnic ventilatory response (HCVR) only in high doses, while DAMGO and morphine diminished the HCVR in much lower doses. The ventilatory effects of high doses of all 4 agonists were blocked by the mu-opioid antagonist naloxone (0.4 mg/kg i.v.), but not by the peripherally restricted mu-opioid antagonist, methyl-naloxone (0.4 mg/kg i.v.). It was concluded that the endomorphins attenuated the HCVR only in large doses, well beyond the analgesic threshold, and did so through a centrally mediated mu-opioid mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1059, Issue 2, 19 October 2005, Pages 159-166
Journal: Brain Research - Volume 1059, Issue 2, 19 October 2005, Pages 159-166
نویسندگان
Marc A. Czapla, James E. Zadina,