کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425439 | 1295872 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Extrasynaptic localization of glycine receptors in the rat supraoptic nucleus: Further evidence for their involvement in glia-to-neuron communication
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کلمات کلیدی
IPSCGABA receptor type Aethylene glycol-bis-(2-aminoethylether)-N,N,N′,N′-tetraacetic acidSynaptic receptorsmIPSCGlyRPBSSNARETTXaCSFGFAPEGTAEPSC - EPSCoRAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPtetrodotoxin - تترو دوتوکسین Osmoregulation - تنظیم فشار اسمزیSynaptic currents - جریان سیناپتیسinhibitory post-synaptic current - جریان فعلی مهارکننده سیناپسیminiature inhibitory post-synaptic current - جریان مینیاتوری پس از سیناپتی مهارکنندهexcitatory post-synaptic current - جریان پسا سیناپتی هیجان انگیزNeuroendocrine cells - سلولهای نوروآندوکرینSON - فرزند پسرartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریSupraoptic nucleus - هسته SupraopticGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالGABAAR - گابارGABAA receptors - گیرنده های GABAAglycine receptor - گیرنده گلیسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Extrasynaptic localization of glycine receptors in the rat supraoptic nucleus: Further evidence for their involvement in glia-to-neuron communication Extrasynaptic localization of glycine receptors in the rat supraoptic nucleus: Further evidence for their involvement in glia-to-neuron communication](/preview/png/9425439.png)
چکیده انگلیسی
Neurons of the rat supraoptic nucleus (SON) express glycine receptors (GlyRs), which are implicated in the osmoregulation of neuronal activity. The endogenous agonist of the receptors has been postulated to be taurine, shown to be released from astrocytes. We here provide additional pieces of evidence supporting the absence of functional glycinergic synapses in the SON. First, we show that blockade of GlyRs with strychnine has no effect on either the amplitude or frequency of miniature inhibitory postsynaptic currents recorded in SON neurons, whereas they were all suppressed by the GABAA antagonist gabazine. Then, double immunostaining of sections with presynaptic markers and either GlyR or GABAA receptor (GABAAR) antibodies indicates that, in contrast with GABAARs, most GlyR membrane clusters are not localized facing presynaptic terminals, indicative of their extrasynaptic localization. Moreover, we found a striking anatomical association between SON GlyR clusters and glial fibrillary acidic protein (GFAP)-positive astroglial processes, which contain high levels of taurine. This type of correlation is specific to GlyRs, since GABAAR clusters show no association with GFAP-positive structures. These results substantiate and strengthen the concept of extrasynaptic GlyRs mediating a paracrine communication between astrocytes and neurons in the SON.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 133, Issue 1, 2005, Pages 175-183
Journal: Neuroscience - Volume 133, Issue 1, 2005, Pages 175-183
نویسندگان
C. Deleuze, G. Alonso, I.A. Lefevre, A. Duvoid-Guillou, N. Hussy,