Keywords: CaMKII; Ca2+-calmodulin-dependent kinase II; ER; endoplasmic reticulum; GABAARs; type-A GABA receptors; IICR; IP3 receptor-dependent calcium release; GLT1; glutamate transporter 1; GlyR; glycine receptor GlyR; mGluRs; metabotropic glutamate receptors; nAc
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Keywords: Food allergy; Free glycine; Mouse model of cow's milk allergy; Mast cells; Basophils; mMCP-1; Mouse mast cell protease-1; CMA; cow's milk allergy; IEC; Intestinal epithelial cells; Ig; immunoglobulin; AA; amino acid; CEAA; conditional essential amino acid
Keywords: 5HT3R; 5-hydroxytryptamine receptor, subtype 3; ATP; Adenosine triphosphate; BK; big potassium channels; Cho; cholesterol; CTD; C-terminal domain; ECD; extracellular domain; ELIC; Erwinia chrysanthemi ligand-gated ion channel; GABAAR; gamma-aminobutyric a
Keywords: Inhibitory neurotransmission; Synaptogenesis; Neuroligin; Human; Synaptic kinetics; Patch-clamp; GlyR; glycine receptor; IPSC; inhibitory postsynaptic current; NL2; neuroligin-2; NL2A; neuroligin-2A; Lindane (PubChem CID: 727); Tricine (PubChem CID: 79784
Keywords: Cys-loop receptor; Pentameric ligand-gated ion channel; Phosphorylation; Conformational changes; Drug discovery; 5-HT3R; 5-hydroxytryptamine type-3 receptor; CamKII; Ca2+/calmodulin-dependent protein kinase; GABAAR; GABA type-A receptor; GlyR; glycine rec
Keywords: Amyotrophic lateral sclerosis; Spinal motor neuron degeneration; Inhibitory circuits; GABA; Glycine; Acetylcholine; Renshaw cell; ALS; amyotrophic lateral sclerosis; SOD1; superoxide dismutase type 1; FALS; familial amyotrophic lateral sclerosis; SALS; sp
Participation of the IKK-α/β complex in the inhibition of the TNF-α/NF-κB pathway by glycine: Possible involvement of a membrane receptor specific to adipocytes
Keywords: TNF-α; Tumor necrosis factor alpha; NF-κB; Nuclear factor kappa B; IL-6; Interleukin 6; GlyR; Glycine receptor; TLRs; Toll-like receptor; ROS; Reactive oxygen species; Glycine; Glycine receptors; Adipocytes; Inflammatory cytokines; IKK-α/β complex; TN
Glycine Transporter-1 and glycine receptor mediate the antioxidant effect of glycine in diabetic rat islets and INS-1 cells
Keywords: AUCs; areas under the curve; BSA; bovine serum albumin; CAT; catalase; DCFH-DA; 2,7-Dichlorodi fluorescein; DM; diabetes mellitus; GlyR; glycine receptor; GlyT1; glycine transporter-1; GSH; glutathione; HG; high glucose; Nox; NADPH oxidase; OGTT; oral glu
Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABAA receptors
Keywords: Ago-PAM; allosteric agonist and positive allosteric modulator; C/R; concentration-response; ECD; extracellular domain; FMP; FLIPR Membrane Potential Blue; GABA; γ-Aminobutyric acid; GABAAR; GABAA receptor; methaqualone; 2-methyl-3-(o-tolyl)-quinazolin-4(
Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor
Keywords: β-ABA; β-aminobutyric acid; β-AIBA; β-aminoisobutyric acid; GlyR; glycine receptor; LBD; ligand-binding domain; MBS; Modified Barth's Saline; Popen; probability of channel being open; SEM; standard error of the mean; Ï; dwell-time; TM; transmembran
Functional characterization of two prokaryotic pentameric ligand-gated ion channel chimeras - role of the GLIC transmembrane domain in proton sensing
Keywords: 5HT3R; serotonin receptor; α-BTX; α-bungarotoxin; AChBP; acetylcholine-binding protein; ECD; extracellular domain; ELIC; Erwinia ligand-gated ion channel; GLIC; Gloebacter ligand-gated ion channel; GlyR; glycine receptor; nAChR; nicotinic acetylcholine
Broflanilide: A meta-diamide insecticide with a novel mode of action
Keywords: EBOB; 4â²-ethynyl-4-n-propylbicycloorthobenzoate; GABA; γ-aminobutyric acid; GABAAR; GABA type A receptor; GABAR; GABA receptor; GlyR; glycine receptor; GluCl; glutamate-gated channel; meta-diamides; 3-benzamido-N-(4-(perfluoropropan-2-yl)phenyl)benzami
Glycine blocks long-term potentiation of GABAergic synapses in the ventral tegmental area
Keywords: aCSF; artificial cerebrospinal fluid; DNQX; 6,7-dinitroquinoxaline-2,3-dione; eIPSC; evoked inhibitory postsynaptic current; GABA; gamma-aminobutyric acid; GABAAR; GABAA receptor; GlyR; glycine receptor; GLYTs; glycine transporters; HFS; high-frequency st
Minireview: Mode of action of meta-diamide insecticides
Keywords: DM-RDL; Drosophila RDL GABA receptor subunit; EBOB; 4â²-ethynyl-4-n-propylbicycloorthobenzoate; GABA; γ-aminobutyric acid; GABAAR; GABA type A receptor; GlyR; glycine receptor; GluCl; glutamate-gated chloride channel; 5-HT3 receptor; serotonin type-3 re
Invited reviewInvestigating ion channel conformational changes using voltage clamp fluorometry
Keywords: Fluorescence; Voltage clamp; Ion channel; Conformational change; Protein structure; 6TM; 6 transmembrane; fUAA; fluorescent unnatural amino acid; GABAAR; GABA A-type receptor; GlyR; glycine receptor; LGIC; ligand-gated ion channel; MTS; methanethiosulphon
Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol
Keywords: EC; extracellular; EC2; effective concentration at 2% of maximal response; EC50; half-maximal effective concentration; GABAAR; γ-aminobutyric acid type A receptor; GlyR; glycine receptor; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; IC; int
Research ReportPostnatal development of glycine receptor subunits α1, α2, α3, and β immunoreactivity in multiple brain stem respiratory-related nuclear groups of the rat
Keywords: 5-HT; serotonin; XII; hypoglossal nucleus; Amb; nucleus ambiguus; ANOVA; analysis of variance; APB; ammonium phosphate buffer; BDNF; brain-derived neurotrophic factor; CN; cuneate nucleus; CNS; central nervous system; GABA; gamma aminobutyric acid; GlyR;
Trifluoroacetate is an allosteric modulator with selective actions at the glycine receptor
Keywords: Anesthetic metabolism; Allosteric modulation; Glycine receptor; GABAA receptor; 5-HT3 receptor; Trifluoroacetate; GlyR; glycine receptor; MBS; Modified Barth's Saline; TFA; trifluoroacetate;
Ensemble and single particle fluorimetric techniques in concerted action to study the diffusion and aggregation of the glycine receptor α3 isoforms in the cell plasma membrane
Keywords: ãr2ã; mean square displacement; Ï0; laser beam radius at 1/e2 of its maximum intensity; CLSM; confocal laser scanning microscope; Dâ²; time-dependent diffusion coefficient; D1-3; diffusion coefficient derived from the time lags 1 to 3; DC; dichroi
Atropine-sensitive hippocampal theta oscillations are mediated by Cav2.3 R-type Ca2+ channels
Keywords: calcium; cognition; theta; CA1; cornu ammonis; CNG; cyclic nucleotide-gated; DAG; diacylglycerole; D2; dopamine type 2; EFHC1; EF-hand C1 protein; GABAAR; γ-aminobutyric acid type A receptor; GC; guanylate cyclase; GlyR; glycine receptor; Gαq/11; G prot
Inhibitory neurotransmission in animal models of tinnitus: Maladaptive plasticity
Keywords: ABR; auditory brainstem response; ANOVA; analysis of variance; CF; characteristic frequency; CN; cochlear nucleus; DCN; dorsal cochlear nucleus; GlyR; glycine receptor; VCN; ventral cochlear nucleus; IC; inferior colliculus; RLF; rate-level function; GAD;
Intrinsically photosensitive ganglion cells of the primate retina express distinct combinations of inhibitory neurotransmitter receptors
Keywords: melanopsin; glycine receptors; GABA receptors; primate retina; GABAAR; GABAA receptor; GABAARα1-3; GABAA receptor subunit α1-3; GlyR; glycine receptor; GlyRα1-3; glycine receptor subunit α1-3; IPL; inner plexiform layer; ipRGC; intrinsically p
Pain Mechanisms and Sensory NeuroscienceResearch PaperAttenuated glycine receptor function reduces excitability of mouse medial vestibular nucleus neurons
Keywords: glycine; mouse; AHP; excitability; AHP; afterhyperpolarization; AP; action potential; FRA; firing rate adaptation; GlyR; glycine receptor; mIPSCs; miniature inhibitory post-synaptic currents; MVN; medial vestibular nucleus; PRD; post-inhibitory rebound de
Clozapine inhibits strychnine-sensitive glycine receptors in rat hippocampal neurons
Keywords: Clozapine; GlyR; Hippocampus; IGly; Dopamine
Neurochemistry of the afferents to the rat cochlear root nucleus: Possible synaptic modulation of the acoustic startle
Keywords: neurotransmitter receptors; receptor expression; VGAT; VGLUT; locus coeruleus; cochlear root neurons; ABC; avidin-biotin-peroxidase complex; ASR; acoustic startle reflex; AVCN; anteroventral cochlear nucleus; BDA; biotinylated dextran amine; CM; confo
Glycine receptors are functionally expressed on bullfrog retinal cone photoreceptors
Keywords: glycine receptor; whole cell recording; cone photoreceptor; retina; immunofluorescence double labeling; [Clâ]o; extracellular chloride concentration; DCKA; 5,7-dichlorokynurenic acid; DMSO; dimethyl sulfoxide; ECl; chloride equilibrium; EC50; concentrat
Frequency-dependent modulation of glycine receptor activation recorded from the zebrafish larvae hindbrain
Keywords: glycine receptors; patch-clamp; desensitization; frequency; synaptic activity; modulation; GABAAR; type A GABA receptor; GlyR; glycine receptor; M-cell; Mauthner cell; mIPSC; miniature inhibitory post-synaptic current; SSE; sum of squared error;
The β subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors
Keywords: Channel block; Ginkgo biloba; Picrotoxin; Specificity; GlyR; Antagonism; EC50; concentration of agonist eliciting a half-maximal peak response; GB; ginkgolide B; GlyR; glycine receptor; Imax; maximal current; nH; Hill coefficient; wt; wild-type;
Male transgenic glycine receptor α1 (S267Q) mutant mice display a hyperekplexia-like increase in acoustic startle responses
Keywords: GlyR; Mice; Transgenic; Acoustic startle response; Glycine; Taurine; Strychnine-sensitive; Ectopic; Chloride flux;
Extrasynaptic localization of glycine receptors in the rat supraoptic nucleus: Further evidence for their involvement in glia-to-neuron communication
Keywords: synaptic currents; GABAA receptors; synaptic receptors; osmoregulation; neuroendocrine cells; aCSF; artificial cerebrospinal fluid; ATP; adenosine triphosphate; EGTA; ethylene glycol-bis-(2-aminoethylether)-N,N,Nâ²,Nâ²-tetraacetic acid; EPSC; excitatory
Structural difference between heteromeric somatic and homomeric axonal glycine receptors in the hypothalamo-neurohypophysial system
Keywords: hypothalamus; neurohypophysis; presynaptic receptors; receptor targeting; taurine; neuroendocrine cells; EDTA; ethylenediamine-tetraacetic acid; EGTA; ethylene glycol-bis-(2-aminoethylether)-N,N,Nâ²,Nâ²-tetraacetic acid; GlyR; glycine receptor; HNS; hyp
Distinct roles of glycinergic and GABAergic inhibition in coordinating locomotor-like rhythms in the neonatal mouse spinal cord
Keywords: locomotor-like rhythm; bilateral rhythm coordination; disinhibition-induced discharges; GABA inhibition; glycine inhibition; mouse spinal cord; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; CV; coefficient variance; d-APV; d-2-amino-5-phosphonovaleric acid;