کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425677 | 1295886 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina
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کلمات کلیدی
SCOSCNIPLEPLCTXHYPcGKcGMPGFAPHABDCNcGKIMAPK - MAPKAmygdala - آمیگدال، بادامهImmunohistochemistry - ایمونوهیستوشیمیPurkinje cell - سلول پورکنژ، یاخته پورکینیهRetina - شبکیهSubcommissural organ - عضو کموبارcerebral cortex - قشر مغزexternal plexiform layer - لایه بیرونی خارجیinternal plexiform layer - لایه داخلی یکپارچهPVN - مالیات بر ارزش افزودهBrain - مغزHIP - مفصل ران یا مفصل هیپNitric oxide - نیتریک اکسیدLateral habenular nucleus - هسته حنجره جانبیdeep cerebellar nuclei - هسته مغناطیسی عمیقparaventricular nucleus - هسته پروژسترویکSuprachiasmatic nucleus - هستههای سوپراکیاسماتیکHypothalamus - هیپوتالاموسdorsomedial hypothalamus - هیپوتالاموس dorsomedialHippocampus - هیپوکامپ Glial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالProtein kinase - پروتئین کینازmitogen-activated protein kinase - پروتئین کیناز فعال با mitogencyclic guanosine-3′,5′-monophosphate - گنوزین سیکل 3 '، 5'-مونوفسفره
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina](/preview/png/9425677.png)
چکیده انگلیسی
Nitric oxide (NO) modulates a variety of processes in the mammalian brain, but the mechanisms of neuronal NO signaling are poorly understood. In the periphery, many effects of NO are mediated via the generation of the second messenger cyclic guanosine-3â²,5â²-monophosphate (cGMP) and activation of the cGMP-dependent protein kinase type I (cGKI). However, previous studies suggested that the expression of cGKI in the nervous system is rather restricted, thus, questioning the functional significance of the cGMP/cGKI pathway as a mediator of NO signaling in the brain. Here we have performed a detailed immunohistochemical study to elucidate the distribution of cGKI in the CNS and eye of the mouse. Expression of cGKI protein was detected not only in the previously described areas (cerebellum, hippocampus, dorsomedial hypothalamus) but also in a number of additional regions, such as medulla, subcommissural organ, cerebral cortex, amygdala, habenulae, various hypothalamic regions, olfactory bulb, pituitary gland, and retina. Immunoblotting with isoform-specific antibodies indicated that the cGKIα isoform is prominent in the cerebellum and medulla, whereas the cGKIβ isoform is predominant in the cortex, hippocampus, hypothalamus, and olfactory bulb. Similar levels of the isoforms were detected in the pituitary gland and eye. Thus, it appears that distinct brain regions express distinct cGKI isoforms that signal via distinct pathways. Together, these results improve our understanding of the cellular and molecular mechanisms of NO/cGMP/cGKI signaling and indicate that the distribution and functional relevance of this pathway in the mammalian brain is broader than previously thought.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 135, Issue 3, 2005, Pages 863-868
Journal: Neuroscience - Volume 135, Issue 3, 2005, Pages 863-868
نویسندگان
S. Feil, P. Zimmermann, A. Knorn, S. Brummer, J. Schlossmann, F. Hofmann, R. Feil,